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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell <t>integrin</t> ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.
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( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell integrin ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.

Journal: Science Advances

Article Title: Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration

doi: 10.1126/sciadv.adx2768

Figure Lengend Snippet: ( A ) The composition and structure of the NP in IVD tissue exhibited spatial heterogeneity, which support NP cell development and physiological function through dynamic mechanical regulation and biochemical signaling. ( B ) Inspired by the partitioned structure of ECM, bioactive sericin was coassembled with BPAA-GFF fibrillar networks, driven by phase separation–induced molecular network rearrangement. The resulting dynamic adaptive network activated stem cell integrin ligands to modulate cell-matrix interactions and promoted chondrogenic differentiation via rapid stress relaxation and biochemical factor induction. ( C ) In rat and rabbit IVD degeneration models, KGN-incorporated coassembled hydrogel effectively promoted BMSCs for NP regeneration.

Article Snippet: To investigate the role of integrin β3 in mediating stem cell adhesion and cytoskeletal regulation, functional inhibition was performed using the αvβ3 integrin antagonist cilengitide (MedChemExpress, USA).

Techniques:

( A ) 3D coculture of stem cells with the coassembled BS gel. ( B ) Time-dependent gene expression trend of stem cells regulated by coassembled BS protein gel. ( C ) Up-regulated genes and their associated biological events based on Gene Ontology (GO) analysis comparing BS versus B. ( D ) Flow relationships between activated molecular pathways and up-regulated genes based on Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis comparing BS versus B. JAK-STAT, Janus kinase–signal transducer and activator of transcription; MAPK, mitogen-activated protein kinase. ( E ) Gene interaction network analysis and Gantt chart analysis of temporal gene expression in three gene categories. ( F ) Gene expression heatmap analysis comparing BS versus B, n = 3 independent samples. ( G ) In vitro validation of gene expression by qPCR, n = 3 independent samples. ( H ) Local interaction residues in molecular docking. Color-coded representation shows BPAA-GFF (green), sericin protein (magenta), and the integrin αvβ3 complex (blue and orange). ( I ) Time-course analysis of stem cells cocultured with the hydrogel at 1, 2, and 4 weeks. ( J ) Integrin β3 expression analysis at 1 week, n = 3 independent samples. ( K ) Cytoskeletal staining and cell aspect ratio analysis at 1 week. ( L ) YAP staining and nuclear/cytoplasmic ratio analysis. ( M ) Coassembled BS gel activates integrin-mediated cell-matrix interactions, driving YAP nuclear translocation and downstream mechanotransduction signaling. Statistical analyses were performed with Student’s t tests (unpaired and two-tailed): * P < 0.05, ** P < 0.01, and *** P < 0.001.

Journal: Science Advances

Article Title: Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration

doi: 10.1126/sciadv.adx2768

Figure Lengend Snippet: ( A ) 3D coculture of stem cells with the coassembled BS gel. ( B ) Time-dependent gene expression trend of stem cells regulated by coassembled BS protein gel. ( C ) Up-regulated genes and their associated biological events based on Gene Ontology (GO) analysis comparing BS versus B. ( D ) Flow relationships between activated molecular pathways and up-regulated genes based on Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis comparing BS versus B. JAK-STAT, Janus kinase–signal transducer and activator of transcription; MAPK, mitogen-activated protein kinase. ( E ) Gene interaction network analysis and Gantt chart analysis of temporal gene expression in three gene categories. ( F ) Gene expression heatmap analysis comparing BS versus B, n = 3 independent samples. ( G ) In vitro validation of gene expression by qPCR, n = 3 independent samples. ( H ) Local interaction residues in molecular docking. Color-coded representation shows BPAA-GFF (green), sericin protein (magenta), and the integrin αvβ3 complex (blue and orange). ( I ) Time-course analysis of stem cells cocultured with the hydrogel at 1, 2, and 4 weeks. ( J ) Integrin β3 expression analysis at 1 week, n = 3 independent samples. ( K ) Cytoskeletal staining and cell aspect ratio analysis at 1 week. ( L ) YAP staining and nuclear/cytoplasmic ratio analysis. ( M ) Coassembled BS gel activates integrin-mediated cell-matrix interactions, driving YAP nuclear translocation and downstream mechanotransduction signaling. Statistical analyses were performed with Student’s t tests (unpaired and two-tailed): * P < 0.05, ** P < 0.01, and *** P < 0.001.

Article Snippet: To investigate the role of integrin β3 in mediating stem cell adhesion and cytoskeletal regulation, functional inhibition was performed using the αvβ3 integrin antagonist cilengitide (MedChemExpress, USA).

Techniques: Gene Expression, In Vitro, Biomarker Discovery, Expressing, Staining, Translocation Assay, Two Tailed Test